Infected with BA.1 Omicron variant? It won’t protect against newer subvariants: study
Global News
People infected with the earliest version of the Omicron variant, first identified in South Africa in November, may be vulnerable to reinfection with later versions of Omicron.
People infected with the earliest version of the Omicron variant of the coronavirus, first identified in South Africa in November, may be vulnerable to reinfection with later versions of Omicron even if they have been vaccinated and boosted, new findings suggest.
Vaccinated patients with Omicron BA.1 breakthrough infections developed antibodies that could neutralize that virus plus the original SARS-CoV-2 virus, but the Omicron sublineages circulating now have mutations that allow them to evade those antibodies, researchers from China reported on Friday in Nature.
Omicron BA.2.12.1, which is presently causing most infections in the United States, and Omicron BA.5 and BA.4, which now account for more than 21% of new U.S. cases, contain mutations not present in the BA.1 and BA.2 versions of Omicron.
Those newer sublineages “notably evade the neutralizing antibodies elicited by SARS-CoV-2 infection and vaccination,” the researchers found in test-tube experiments.
The monoclonal antibody drugs bebtelovimab from Eli Lilly and cilgavimab, a component of AstraZeneca’s Evusheld, can still effectively neutralize BA.2.12.1 and BA.4/BA.5, the experiments also showed.
But vaccine boosters based on the BA.1 virus, such as those in development by Pfizer/BioNTech and Moderna, “may not achieve broad-spectrum protection against new Omicron variants,” the researchers warned.
Previous research that has not yet undergone peer review has suggested that unvaccinated people infected with Omicron are unlikely to develop immune responses that will protect them against other variants of the coronavirus.
“My personal bias is that while there may be some advantage to having an Omicron-specific vaccine, I think it will be of marginal benefit over staying current with the existing vaccines and boosters,” said Dr. Onyema Ogbuagu, and infectious diseases researcher at Yale School of Medicine in New Haven, Connecticut who was not involved in the new study.
The motion won't mean the city is investing or accepting payment in cryptocurrency any time soon, but will instead direct staff to look into those possibilities.
Enbridge officials said in a statement that the reroute proposal has gone through rigorous reviews and studies.
A proposed deal that would see three tobacco giants pay out billions to provinces and territories, as well as smokers across Canada, has been approved by the companies' creditors.
Tokyo recently announced a four-day workweek policy in an effort to boost Japan’s record-low fertility rate - something that Canada is also struggling with.
More than 1,500 firefighters were battling the blaze, many working in steep canyons, according to the California Department of Forestry and Fire Protection, known as Cal Fire.
Evidence has grown in recent years that highly processed foods are linked to a wide range of chronic health problems, like diabetes and heart disease.
Environment and Climate Change Canada has released its list of the top 10 most impactful weather events of 2024.
Fifteen charges under the federal Fisheries Act have been laid against Imperial Metals Corp. more than 10 years after a tailings pond collapsed the Mount Polley mine.
Many kids and teens are looking forward to the holidays with great excitement, but others find it a difficult time of year filled with anxiety, stress and loneliness. It’s something Alisa Simon, the chief youth officer at Kids Help Phone, says they watch for when school pauses for the winter break, noting, “we do see an increase...
Advocates and friends of a Nova Scotia woman who died from stage IV breast cancer are urging the province to update its screening policy for women with dense breast tissue.
The report estimates a cancer patient will face almost $33,000 on average in out-of-pocket cancer-related costs in their lifetime, including loss of income.