Explained| AlphaFold: A tour de force in science
The Hindu
How have our methods of predicting protein structures changed with AI-based tools? What does this development signify for structural biology?
The story so far: DeepMind, a company based in London and owned by Google, announced this week that it had predicted the three-dimensional structures of more than 200 million proteins using AlphaFold. This is the entire protein universe known to scientists today.
AlphaFold is an AI-based protein structure prediction tool. It is based on a computer system called deep neural network. Inspired by the human brain, neural networks use a large amount of input data and provides the desired output exactly like how a human brain would. The real work is done by the black box between the input and the output layers, called the hidden networks. AlphaFold is fed with protein sequences as input. When protein sequences enter through one end, the predicted three-dimensional structures come out through the other. It is like a magician pulling a rabbit out of a hat.
It uses processes based on “training, learning, retraining and relearning.” The first step uses the available structures of 1,70,000 proteins in the Protein Data Bank (PDB) to train the computer model. Then, it uses the results of that training to learn the structural predictions of proteins not in the PDB. Once that is done, it uses the high-accuracy predictions from the first step to retrain and relearn to gain higher accuracy of the earlier predictions. By using this method, AlphaFold has now predicted the structures of the entire 214 million unique protein sequences deposited in the Universal Protein Resource (UniProt) database.
Proteins are the business ends of biology, meaning proteins carry out all the functions inside a living cell. Therefore, knowing protein structure and function is essential to understanding human diseases. Scientists predict protein structures using x-ray crystallography, nuclear magnetic resonance spectroscopy, or cryogenic electron microscopy. These techniques are not just time-consuming, they often take years and are based mainly on trial-and-error methods. The development of AlphaFold changes all of that. It is a watershed movement in science and structural biology in particular.
AlphaFold has already helped hundreds of scientists accelerate their discoveries in vaccine and drug development since the first public release of the database nearly a year back.
From the seminal contribution of G. N. Ramachandran in understanding protein structures to the present day, India is no stranger to the field and has produced some fine structural biologists. The Indian community of structural biology is strong and skilled. It needs to quickly take advantage of the AlphaFold database and learn how to use the structures to design better vaccines and drugs. This is especially important in the present context. Understanding the accurate structures of COVID-19 virus proteins in days rather than years will accelerate vaccine and drug development against the virus.
India will also need to speed up its implementation of public-private partnerships in the sciences.
One of the goals at the ninth edition of Film Heritage Foundation’s ‘travelling school’ in Kerala was to go beyond Bollywood
Genetically modified crops offer sustainable solutions to food production challenges, but long-term effects on health and environment remain uncertain.
An unusual cluster of typhoons in the West Pacific and a series of powerful hurricanes in the Atlantic are raising questions about the impact that climate change is having on tropical storms across the globe.
Experience Lucknow's culinary heritage at Khaas, a North Indian restaurant in Chennai offering authentic kebabs and biryanis.
We know birds, animals and insects constantly communicate with each other by making certain sounds. But when we think about plants, we do not ever think of them communicating. Charles Darwin, an eminent biologist, thought otherwise. Plants might appear the quiet, silent and solitary type of organisms but they have a complex way of communicating which is interesting and important for their survival.
Flight six of Starship was seen as a test of whether SpaceX’s first booster catch was pure precision or relied on a stroke of luck.
Discover the fascinating science behind how a pencil writes, from carbon atoms to condensed matter physics explained concisely.
North American cicadas have life cycles that last for prime numbers of years, putting pressure on the idea that humans created mathematics.
Stationary objects balance on a wide base due to gravity, while moving vehicles balance due to forward force.
The Ministry of Defence expects the MoA to enable the two organisations to access testing facilities available with each other for mutual benefit.
Research has uncovered the transmission of pathogens between managed honey bees and wild pollinators, a process called pathogen spillover and spillback