Drug slows Alzheimer's but can it make a real difference?
CTV
An experimental Alzheimer's drug modestly slowed the brain disease's inevitable worsening, researchers reported Tuesday – but it remains unclear how much difference that might make in people's lives.
An experimental Alzheimer's drug modestly slowed the brain disease's inevitable worsening, researchers reported Tuesday – but it remains unclear how much difference that might make in people's lives.
Japanese drugmaker Eisai and its U.S. partner Biogen had announced earlier this fall that the drug lecanemab appeared to work, a badly needed bright spot after repeated disappointments in the quest for better Alzheimer's treatments.
Now the companies are providing full results of the study of nearly 1,800 people in the earliest stages of the mind-robbing disease. The data was presented at an Alzheimer's meeting in San Francisco and published in The New England Journal of Medicine. U.S. regulators could approve the drug as soon as January.
Every two weeks for 18 months, study participants received intravenous lecanemab or a dummy infusion. Researchers tracked them using an 18-point scale that measures cognitive and functional ability.
Those given lecanemab declined more slowly – a difference of not quite half a point on that scale, concluded the research team led by Dr. Christopher van Dyck at Yale University.
That's a hard-to-understand change, but measured a different way, lecanemab delayed patients' worsening by about five months over the course of the study, Eisai's Dr. Michael Irizarry told The Associated Press. Also, lecanemab recipients were 31% less likely to advance to the next stage of the disease during the study.
"That translates to more time in earlier stages" when people function better, Irizarry said.
Pressure is increasing on the provincial government to tap into the underused tolled Highway 407 to unclog congestion on Highway 401.
The first big snowfall of the season is blanketing towns in upstate New York along lakes Erie and Ontario in the middle of the hectic holiday travel and shopping weekend, while numbing cold and heavy snow could persist into next week and cause hazards in the Great Lakes, Plains and Midwest regions.
Researchers in Montreal have made a breakthrough discovery in HIV research by finding a way to expel the virus from its hiding places and destroy it.
Concerns about the safety of candles are rooted in the chemical reactions that occur when you burn them, as well as in the artificial fragrances and colorants that contribute to the various scents you may love.