Demi Moore Says She Lost 20 Pounds, Broke Out In Shingles From 'Intensity' Of Latest Role

The "Substance" star says she "put it all on the table" for her buzzed-about performance in the anticipated body-horror film.

Demi Moore says she “put it all on the table” for her latest role, but not without consequences.

Moore stars as a fictional A-list actor in “The Substance,” a buzzed-about body-horror flick about a new drug that allows customers to birth a younger, prettier version of themselves. Naturally, things go very much awry in the film — and apparently did in real life, too.

“To give you an idea of the intensity, my first week that I actually had off, where it was just Margaret [Qualley] working, I got shingles,” Moore told the Los Angeles Times in an expansive interview Tuesday, adding: “And I then lost, like, 20 pounds.”

Shingles is a viral infection that can occur anywhere on the body and result in a painful rash. The varicella-zoster virus, which is the same one that causes chickenpox, that’s responsible for shingles can reactivate years after initial exposure — often due to stress.

“Oh, yeah,” Qualley interjected, “I had crazy acne for a full, long-ass time.”