'An unusual approach': Canadian scientists exploring use of carbon monoxide to treat sepsis

Researchers in London, Ont. are studying the use of a susprising gas as a possible option to treat sepsis: carbon monoxide.

Researchers in London, Ont. are studying the use of a susprising gas as a possible option to treat sepsis: carbon monoxide.

A life-threatening condition that occurs when the body’s response to an infection triggers excessive inflammation, sepsis can cause damage to organs such as the heart, liver, lungs and brain.

While there are currently limited treatments for sepsis, researchers at Lawson Health Research Institute are working to change that by examining the use of carbon monoxide-releasing molecules to treat patients.

“This is an unusual approach that is looking at using carbon monoxide which is the infamous gas molecule,” said Dr. Gedas Cepinskas, scientist and director of the Centre for Critical Illness Research at Lawson. “If administered and used in small non-toxic concentrations, carbon monoxide can offer very potent protective and anti-inflammatory effects.”

In studies on the subject, the research team was able to demonstrate efficacy in using carbon monoxide-releasing molecules to protect individual cells in the liver and lungs of sepsis induced inflammation in preclinical models.

spe“We have been working on isolated organs and organ specific cells to test carbon monoxide-releasing molecules to narrow down which specific cells are more sensitive to treatment and which biochemical pathways are involved,” said Cepinskas. “We are making great progress in our work and have had success in addressing the efficacy of carbon monoxide-releasing molecules in preclinical models.”

Dr. Cepinskas is one of just a few scientists worldwide studying carbon monoxide-releasing molecules to treat inflammatory conditions such as sepsis.