2021 NFL Week 1 Picks, Odds: Raiders stun Ravens, Bills crush Steelers, Cardinals upset Titans

All of Will Brinson's picks and best bets for Week 1 of the 2021 NFL season

Football! It's back, it's real and it's spectacular. While there's still a pandemic in the background, it feels vastly different from a year ago, when football legitimately could have just disappeared. Now we have fans in the stands and it could present some interesting betting opportunities -- at the very least it's going to create wildly different game situations for these players. After a year of being able to easily communicate in empty stadiums, quarterbacks now will have to adjust to mildly different environments. If you don't believe me, watch this goosebumps-inducing video of Virginia Tech blasting "Enter Sandman" ahead of its huge upset of North Carolina last Friday night.  There are at least three starting quarterbacks -- Justin Herbert, Tua Tagovailoa and Joe Burrow -- who have not played against NFL defenses on the road with full stadiums of fans losing their minds. I'm not suggesting they'll crumble or anything this season, but road games are going to be more difficult (and probably some home games for Herbert). It felt like college football delivered a pretty big home-field advantage in some situations. So the trend warrants monitoring this week in the NFL as well.