NIH finds potential coronavirus oral antiviral drug
Fox News
The National Institutes of Health (NIH) on Thursday announced a potential oral antiviral treatment to lessen the severity of COVID-19 disease, ahead of clinical studies assessing efficacy in patients.
"We urgently need additional effective, accessible treatments for COVID-19," Dr. Diana W. Bianchi, National Institute of Child Health and Human Development (NICHD) director, said in a statement posted Thursday. "An oral drug that prevents SARS-CoV-2 from replicating would be an important tool for reducing the severity of the disease." A team of researchers with Dr. Tracey A. Rouault, head of the NICHD arm on Human Iron Metabolism, uncovered the drug's potential by analyzing how the virus replicates in cells. The enzyme under study, RNA replicase, functions best with two so-called iron-sulfur clusters, whereas previous studies incorrectly pinned the structures as zinc-binding sites, according to the NIH.
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