New light on how insulin signalling affects tissue health

Inputs from the fasted insulin levels created a memory that improved the fed insulin inputs, finds a study

In a study that examined the effect of insulin on liver cells taken from mice, researchers have uncovered how insulin amounts shape the flow of information through the signalling network. The study also provides insights into the degree to which major and minor components are important in keeping this signalling process intact. This knowledge can direct further studies to identify targets for therapy.

Insulin is a hormone secreted by the b cells of the pancreas. It is commonly associated with an ability to regulate glucose metabolism. However, later studies (from around 1949 until recently) have shown it plays a larger role and helps in growth and maintenance of tissues. Despite years of study, fundamental details as to how differential amounts of insulin impact cells are unknown.